CCN1 stimulated the osteoblasts via PTEN/AKT/GSK3 β /cyclinD1 signal pathway in Myeloma Bone Disease
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چکیده
منابع مشابه
CCN1 Induces Oncostatin M Production in Osteoblasts via Integrin-Dependent Signal Pathways
Inflammatory response and articular destruction are common symptoms of osteoarthritis. Cysteine-rich 61 (CCN1 or Cyr61), a secreted protein from the CCN family, is associated with the extracellular matrix involved in many cellular activities like growth and differentiation. Yet the mechanism of CCN1 interacting with arthritic inflammatory response is unclear. This study finds CCN1 increasing ex...
متن کاملMultiple myeloma bone disease: targeting osteoclasts and osteoblasts
Good bone health depends on a balance between bone formation carried out by osteoblasts and bone resorption carried out by osteoclasts. Of the many factors that can tilt this equilibrium, two key molecular signaling pathways stand out. On one side is the receptor activator of nuclear factor B (RANK) / RANK ligand (RANKL) pathway. Here, osteoblasts produce RANKL that binds to its receptor, RANK...
متن کاملMULTIPLE MYELOMA BONE DISEASE: PATHOPHYSIOLOGY OF OSTEOBLAST INHIBITION. Short title: Multiple myeloma and osteoblasts
Multiple myeloma (MM) is a plasma cell malignancy characterized by a high capacity to induce osteolytic bone lesions. Bone destruction in MM results from increased osteoclast formation and activity that occur in close proximity to myeloma cells. However, histomorphometric studies have demonstrated that MM patients with osteolytic bone lesions have lower numbers of osteoblasts and decreased bone...
متن کاملMULTIPLE MYELOMA Myeloma bone disease
Bone destruction is a hallmark of multiple myeloma, and recent studies demonstrated a strong interdependence between tumor progression and bone resorption. Increased bone resorption as a major characteristic of multiple myeloma is caused by osteoclast activation and osteoblast inhibition (uncoupling). Myeloma cells alter the local regulation of bone metabolism by increasing the receptor activat...
متن کاملSignal transduction in electrically stimulated bone cells.
BACKGROUND Electrical stimulation is used to treat nonunions and to augment spinal fusions. We studied the biochemical pathways that are activated in signal transduction when various types of electrical stimulation are applied to bone cells. METHODS Cultured MC3T3-E1 bone cells were exposed to capacitive coupling, inductive coupling, or combined electromagnetic fields at appropriate field str...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2019
ISSN: 2045-7634,2045-7634
DOI: 10.1002/cam4.2608